Compile Data Set for Download or QSAR
maximum 50k data
Found 419 of ic50 data for polymerid = 8015,50000744
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118519(CHEMBL3617050)
Affinity DataIC50:  0.00600nMAssay Description:Inhibition of NaV1.2 channel (unknown origin) expressed in Xenopus laevis oocytes by two-electrode oocyte voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118514(CHEMBL3617063 | US9481677, 38)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of full length human Nav1.2 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233223(CHEMBL4060338)
Affinity DataIC50:  0.280nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced tail current by whole cell patch clamp method re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233223(CHEMBL4060338)
Affinity DataIC50:  0.450nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced sustained current by whole cell patch clamp meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50:  1nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233224(CHEMBL4070670)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced tail current by whole cell patch clamp method re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Nav1.2 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -35 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233224(CHEMBL4070670)
Affinity DataIC50:  2.10nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced sustained current by whole cell patch clamp meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human Nav1.2 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051090(CHEMBL3318149)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051091(CHEMBL3318150)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50:  3nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051089(CHEMBL3318148)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169425(CHEMBL3341983 | US9481677, 44)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of full length human Nav1.2 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM145466(US8952169, 245)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Nav1.2 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -35 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM268418(N-(7-(adamantan-1-ylmethoxy)-6-ethyl-[1,2,4]triazo...)
Affinity DataIC50:  7nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.2 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233222(CHEMBL4082248)
Affinity DataIC50:  7.5nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced sustained current by whole cell patch clamp meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051088(CHEMBL3318147)
Affinity DataIC50:  8nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051075(CHEMBL3318134)
Affinity DataIC50:  8nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM268527(N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...)
Affinity DataIC50:  10nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.2 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50:  12nMAssay Description:Inhibition of human Nav1.2 by V1/2 protocol based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM268423(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...)
Affinity DataIC50:  14nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.2 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50:  14nMAssay Description:Inhibition of Na+ influx in chinese hamster ovary cells expressing rat brain sodium channel type IIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50:  19nMAssay Description:Inhibition of full length human Nav1.2 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50:  20nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051077(CHEMBL3318136)
Affinity DataIC50:  24nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233221(CHEMBL4064160)
Affinity DataIC50:  26nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced sustained current by whole cell patch clamp meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051084(CHEMBL3318143)
Affinity DataIC50:  28nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50242509(CHEMBL4068937)
Affinity DataIC50:  29nMAssay Description:Inhibition of Nav1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50: <30nMAssay Description:Inhibition of voltage-gated Na channel 1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051079(CHEMBL3318138)
Affinity DataIC50:  33nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233222(CHEMBL4082248)
Affinity DataIC50:  35nMAssay Description:Antagonist activity at human Nav1.2 expressed in HEK293T cells assessed as inhibition of VTD-induced tail current by whole cell patch clamp method re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50118517(CHEMBL3617067)
Affinity DataIC50:  36nMAssay Description:Inhibition of rat NaV1.2 channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  38nMAssay Description:Inhibition of full length human Nav1.2 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051073(CHEMBL3318132)
Affinity DataIC50:  41nMAssay Description:Inhibition of Nav1.2 (unknown origin) expressed in xenopus oocytes at -80 mV holding potential by two-electrode voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051082(CHEMBL3318141)
Affinity DataIC50:  45nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051076(CHEMBL3318135)
Affinity DataIC50:  45nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50262566((2S,3S)-3-[(1R)-6-Methoxy-1-methyl-1-trifluorometh...)
Affinity DataIC50:  48nMAssay Description:Displacement of [3H]batrachotoxinin from rat sodium channel type 2A subunit expressed in CHO-CNa2A cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051081(CHEMBL3318140)
Affinity DataIC50:  50nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329209(5-(4-chlorophenyl)-N-(2-(piperidin-1-yl)benzyl)nic...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human NaV1.2 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051086(CHEMBL3318145)
Affinity DataIC50:  51nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066059(1,3-Bis-(4-sec-butyl-phenyl)-tetrahydro-pyrimidin-...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066062(1,3-Bis-(4-sec-butyl-phenyl)-imidazolidin-2-yliden...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051083(CHEMBL3318142)
Affinity DataIC50:  63nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329205(5-(4-chlorophenyl)-N-((2-(piperidin-1-yl)pyridin-3...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human NaV1.2 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051073(CHEMBL3318132)
Affinity DataIC50:  79nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051080(CHEMBL3318139)
Affinity DataIC50:  98nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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